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The U.S. Food and Drug Administration has approved the usage of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to help manage chronic obesity in older adults with a body mass index (BMI) of more than 27, provided that they also suffer from weight-related medical issues such as Tupe2 diabestes, high-cholesterol and/or hypertension (high blood pressure levels).Contrave can be a combination of two FDA-approved drugs, naltrexone and bupropion, in a extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion is eligible to treat depression and seasonal affective disorder so when an aid to smoking cessation treatment.'Obesity continues to be a major public health concern,' said Jean-Marc Guettier, M.D., director from the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination using a healthy lifestyle that includes a reduced-calorie eating and working out, Contrave provides another treatment option for chronic weight-loss for people who are obese or are overweight and have at least one weight-related health problem.'The drug's effectiveness was evaluated in multiple many studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for one year. All patients received lifestyle modification that was comprised of a reduced- calorie diet and regular physical activity. Results from a clinical study that enrolled patients without diabetes indicated that patients had a normal weight loss of 4.1% rather than participants have been given placebos) during a 12- month period, while a different study involving patients with diabetes type 2 had a normal weight loss of 2% over treatment with placebo at one year.

Using two separate drugs to shed pounds can be very effective you can find combinations while watching FDA now awaiting approval. When dealing with weight loss and the people that go through it you need to err along the side of caution and allow FDA do its job and demand some research be done so that the public is aware of the side effects and hazards of the medications before we take them. Keep in mind that drug companies come in business to earn money and that they would say almost anything to keep people on the medications.

Researchers found out that participants investing in this drug to get a year, dropped a few pounds within 4 weeks and have kept the body weight off through the entire 56 weeks in the study. Contrave is a combination in the drugs naltrexone and bupropion, which seems to reflect a whole new trend of weight-loss drugs which might be made up of more than one active ingredient, which can make them far better and safer.

Combo-pilling is the newest fad or better yet the newest to come under scrutiny and for that reason it is just more publicly known lately, comb-pilling for losing weight has been around since the eighties. The biggest reason that using a combination of pills has become popular will be the fact that since right now there are no long term prescription diet pills that have been licensed by the FDA other than orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications and some of the combinations are already rejected or have yet to be authorized by the FDA.

Seizures certainly are a side effect with Contrave and shouldn't be taken in people with seizure disorders. The drug can also raise blood pressure levels and heartrate, and must not be used in those with a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise blood pressure level and pulse rate and must stop used in patients with uncontrolled high blood pressure level, as well as by you are not heart-related and cerebrovascular (blood vessel dysfunction impacting mental performance) disease. Patients having a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes which has a boxed warning to alert medical researchers and patients towards the increased risk of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for smoking cessation.


"This may be the first drug I'm conscious of that targets the two appetite and reward centres inside brain," he was quoted saying.